PREPARATION AND ADMINISTRATION
Calculate VYXEOS dose based on patient’s BSA and determine the number of vials required.
Remove the vials of VYXEOS from the refrigerator and equilibrate at room temperature for 30 minutes.
DO NOT HEAT
Reconstitute each vial with 19 mL of sterile water for injections using a 20 mL sterile syringe and start a 5-minute timer immediately. Carefully swirl the contents of the vial for 5 minutes while gently inverting the vial every 30 seconds.
Rest for 15 minutes after reconstitution. If the reconstituted product is not immediately diluted into an infusion bag, store in a refrigerator (2°C to 8°C) for up to 4 hours.
DO NOT VORTEX OR SHAKE VIGOROUSLY
Gently invert each vial 5 times prior to withdrawing the concentrate for dilution.
Aseptically withdraw the calculated volume of reconstituted VYXEOS from the vial(s) with a sterile syringe and transfer it to an infusion bag containing 500 mL of sodium chloride 9 mg/mL (0.9%) solution for injection, or 5% glucose.
Discard any unused portions.
Gently invert the bag to mix the solution. If the diluted infusion solution is not used immediately, store in a refrigerator (2°C to 8°C) for up to 4 hours.
VYXEOS is administered by intravenous infusion over a period of 90 minutes. Care should be taken to ensure there is no extravasation to prevent the risk of tissue necrosis.
RECONSTITUTING VYXEOS
Watch this demonstration on how VYXEOS can be reconstituted and prepared prior to dosing.